Regulation of low density lipoprotein receptors by plasma lipoproteins from patients with abetalipoproteinemia.
نویسندگان
چکیده
منابع مشابه
Regulation of Low Density Lipoprotein Receptors
Membranes prepared from the adrenal gland of mice and rats possess high affinity binding sites that recognize '261-labeled human low density lipoprotein (LDL). These binding sites resemble the functional LDL receptors that mediate the uptake of LDL by cultured mouse and bovine adrenal cells. The number of LDL binding sites per mg of membrane protein increased 2to 5-fold over 24 h when mice or r...
متن کاملSelective removal of apolipoprotein B-containing serum lipoproteins from blood plasma (extracorporeal blood filtration/monospecific anti-low density lipoprotein-Sepharose/plasma low density lipoprotein immunoadsorption/ kinetics of low density lipoprotein replenishment/low density lipoprotein adsorption by heparin-Sepharose 4B)
Studies were undertaken to determine the applicability and effectiveness of immunoadsorption chromatography on anti-low density lipoprotein (LDL) columns as a plasma-cholesterol-lowering procedure. Mass production and isolation of monospecific antibodies against swine LDL (p = 1.006-1.063 g/ml) was carried out by immunization of sheep with swine LDL and selective antibody adsorption from their ...
متن کاملAbnormalities of high density lipoproteins in abetalipoproteinemia.
DETAILED STUDIES OF THE HIGH DENSITY LIPOPROTEINS FROM THREE PATIENTS WITH ABETALIPOPROTEINEMIA HAVE REVEALED THE FOLLOWING PRINCIPAL ABNORMALITIES: 1) High density lipoprotein 3 (HDL3) is reduced in both absolute and relative concentration, although HDL2 is present in normal amounts. 2) The phospholipid distribution of both HDL fractions is abnormal, with low concentrations of lecithin and an ...
متن کاملRegulation of plasma low density lipoprotein levels in postmenopausal women.
To study the regulation of plasma low density lipoprotein (LDL) cholesterol in postmenopausal women (n = 79), fasting plasma lipids and lipoproteins, the fractional catabolic rate (FCR) and production rate for LDL apolipoprotein B (apo B), cholesterol absorption, apolipoprotein E phenotype and polymorphisms of the apo B and 7alpha-hydroxylase genes were determined. The level of LDL cholesterol ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.11.3475